Modeling of the hemodynamic responses in block design fMRI studies

作者：Shan Zuyao Y^*; Wright Margaret J; Thompson Paul M; McMahon Katie L; Blokland Gabriella G A M; de Zubicaray Greig I; Martin Nicholas G; Vinkhuyzen Anna A E; Reutens David C

来源：Journal of Cerebral Blood Flow and Metabolism, 2014, 34(2): 316-324.

DOI：10.1038/jcbfm.2013.200

• fMRI
• hemodynamic response
• hemodynamic response function
• test-retest reliability

The hemodynarnic response HRF) describes the local response of brain vasculature to functional activation. Accurate HRF modeling enables the investigation of cerebral blood flow regulation and improves our ability to interpret fMRI results. Block designs have been used extensively as fMRI paradigms because detection power is maximized; however, block designs are not optimal for HRF parameter estimation. Here we assessed the utility of block design fMRI data for HRF modeling. The trueness (relative deviation), precision (relative uncertainty), and identifiability (goodness-of-fit) of different HRF models were examined and test-retest reproducibility of HRF parameter estimates was assessed using computer simulations and fMRI data from 82 healthy young adult twins acquired on two occasions 3 to 4 months apart. The effects of systematically varying attributes of the block design paradigm were also examined. In our comparison of five HRF models, the model comprising the sum of two gamma functions with six free parameters had greatest parameter accuracy and identifiability. Hemodynamic response function height and time to peak were highly reproducible between studies and width was moderately reproducible but the reproducibility of onset time was low. This study established the feasibility and test-retest reliability of estimating HRF parameters using data from block design fMRI studies.

• 出版日期2014-2
• 单位河北医科大学