Anticancer activity of Schiff base-Poloxamer P85 combination against kidney cancer

作者：Dogan Aysegul^*; Demirci Selami; Telci Dilek; Canikyan Serli; Kongur Merve; Dede Bulent; Sahin Fikrettin

来源：International Urology and Nephrology, 2018, 50(2): 247-255.

DOI：10.1007/s11255-017-1782-9

• Schiff base
• Pluronic
• P85
• Renal cell carcinoma
• Chemotherapy

Renal cell carcinoma (RCC) accounts for approximately 80% of the primary renal cancers, and current treatment strategies are not sufficient to provide a certain solution. Since there are not many treatment options, interest in discovery of alternative drugs has increased.
In the current study, anticancer activity of a novel heterodinuclear Cu(II)-Mn(II) complex (Schiff base-SB) in combination with poly(ethylene oxide) and poly(propylene oxide) block copolymer (pluronic) P85 was tested against RCC. Cell viability, apoptosis and gene expression analysis were conducted in vitro by using Renca cells.
The results revealed that the SB-P85 combination decreased cell proliferation by increasing the apoptotic gene expressions and apoptosis. Renca-injected BALB/c mice were used to mimic early stage of RCC model. Treatment with SB-P85 combination suppressed tumor formation and growth compared to baseline.
Overall, SB-P85 showed promising anticancer activity against RCC in vitro and in vivo.

• 出版日期2018-2
• 单位NIH