A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity

作者：Vikneswaran R; Syafiq Muhamad Syamir; Eltayeb Naser Eltaher; Kamaruddin Mohd Naqiuddin; Ramesh S^*; Yahya R

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2015, 150: 175-180.

DOI：10.1016/j.saa.2015.05.087

• Thiosemicarbazone
• Fluorescent
• Chemosensor
• DNA binding
• Chemical nucleases

Copper ion recognition and DNA interaction of a newly synthesized fluorescent Schiff base (HPyETSC) were investigated using UV-vis and fluorescent spectroscopy. Examination using these two techniques revealed that the detection of copper by HPyETSC is highly sensitive and selective, with a detection limit of 0.39 mu m and the mode of interaction between HPyETSC and DNA is electrostatic, with a binding constant of 8.97 x 10(4) M-1. Furthermore, gel electrophoresis studies showed that HPyETSC exhibited nuclease activity through oxidative pathway.

• 出版日期2015-11-5