A simple three-component synthesis of spiro-pyran derivatives

作者:He Yi; Guo Hongyun*; Tian Jinjin
来源:Journal of Chemical Research, 2011, 35(9): 528-530.
DOI:10.3184/174751911X13149692358913

摘要

A series of spiro-pyran derivatives have been synthesised by a three-component reaction of ninhydrin or acenaphthenequinone, malononitrile and 1,3-dicarbonyl compounds such as cyclohexane-1,3-dione, dimedone and barbituaric acid in ethanol with NaHCO(3) as the catalyst. This method has the advantages of easy work-up, mild reaction condition, high yields and it is cheap.