Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation

作者：Di MarcoVieira Bruno; Radford Rowan A; Chung Roger S; Guillemin Gilles J; Pountney Dean L^*

来源：Frontiers in Cellular Neuroscience, 2015, 9: 437.

DOI：10.3389/fncel.2015.00437

• multiple system atrophy
• alpha-synuclein
• neuroinflammation
• astrocytes
• microglia

Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions (GC15) rich in alpha-synuclein (alpha-syn) constitute the disease hallmark, accompanied by neuronal loss and activation of glial cells which indicate neuroinflammation. Recent studies demonstrate that alpha-syn may be released from degenerating neurons to mediate formation of abnormal inclusion bodies and to induce neuroinflammation which, interestingly, might also favor the formation of intracellular alpha-syn aggregates as a consequence of cytokine release and the shift to a pro-inflammatory environment. Here, we critically review the relationships between alpha-syn and astrocytic and microglial activation in MSA to explore the potential of therapeutics which target neuroinflammation.

• 出版日期2015-11-12