Nanoscale Resolution 3D Printing with Pin-Modified Electrified Inkjets for Tailorable Nano/Macrohybrid Constructs for Tissue Engineering

作者：Kim Jeong In; Kim Cheol Sang^*

来源：ACS Applied Materials & Interfaces, 2018, 10(15): 12390-12405.

DOI：10.1021/acsami.7b19182

• 3D printing
• pin-motion electrospinning
• 3D scaffold
• biomedical technology
• tissue engineering

Cells respond to their microenvironment, which is of a size comparable to that of the cells. The macroscale features of three-dimensional (3D) printing struts typically result in whole cell contact guidance (CCG). In contrast, at the nanoscale, where features are of a size similar to that of receptors of cells, the response of cells is more complex. The cell nanotopography interaction involves nanoscale adhesion localized structures, which include cell adhesion-related particles that change in response to the dustering of integrin. For this reason, it is necessary to develop a technique for manufacturing tailorable nano/macrohybrid constructs capable of freely controlling the cellular activity. In this study, a hierarchical 3D nano- to microscale hybrid structure was fabricated by combinational processing of 3D printing and electrified inkjet spinning via pin motions. This method overcomes the disadvantages of conventional 3D printing, providing a novel combinatory technique for the fabrication of 3D hybrid constructs with excellent cell proliferation. Through a pin-modified electrified inkjet spinning, we have successfully fabricated customizable nano-/microscale hybrid constructs in a fibrous or mesh form, which can control the cell fate. We have conducted this study of cell topography interactions from the fabrication approach to accelerate the development of next-generation 3D scaffolds.

• 出版日期2018-4-18