ERK and cell death: ERK1/2 in neuronal death

作者：Subramaniam Srinivasa^*; Unsicker Klaus

来源：FEBS Journal, 2010, 277(1): 22-29.

DOI：10.1111/j.1742-4658.2009.07367.x

• Akt
• PKB
• apoptosis
• caspase
• cell survival
• ERK
• ischemia
• neurodegenerative disease
• neuronal death
• sustained ERK
• transient ERK

Extracellular signal-regulated kinase (ERK) is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that ERK1/2 plays a crucial role in promoting cell death in a variety of neuronal systems, including neurodegenerative diseases. It is believed that the magnitude and the duration of ERK1/2 activity determine its cellular function. In this review, we summarize recent evidence for a role of ERK1/2 in neuronal death. Furthermore, we discuss the mechanisms involved in ERK1/2 mediating neuronal death.

• 出版日期2010-1