Direct, Metal-Free Synthesis of Benzyl Alcohols and Deuterated Benzyl Alcohols from p-Toluenesulfonylhydrazones Using Water as Solvent

作者:Garcia Munoz Angel; Ortega Arizmendi Aldo I; Garcia Carrillo Mario A; Diaz Eduardo; Gonzalez Rivas Nelly; Cuevas Yanez Erick*
来源:Synthesis, 2012, 44(14): 2237-2242.
DOI:10.1055/s-0031-1290372

摘要

A novel library of diverse alcohols was synthesized by metal-free couplings of diazoalkanes derived from p-toluenesulfonylhydrazones to water under reflux and microwave conditions, in high yields. In addition, this protocol was successfully applied in the synthesis of deuterium-labeled alcohols using deuterium oxide.

  • 出版日期2012-7