A rare case report of heavy dose colchicine induced acute kidney injury

作者：Zhong, Hongzhen; Zhong, Zhiqing; Li, Hongyan; Zhou, Tianbiao^*; Xie, Weiji

来源：BMC Pharmacology & Toxicology, 2018, 19(1): 69.

DOI：10.1186/s40360-018-0260-z

• Colchicine
• Acute colchicine intoxication
• Acute kidney injury
• Continuous renal replacement therapy (CRRT)
• Treatment

BackgroundColchicine is a natural alkaloid that is mainly used for the treatment of inflammatory diseases. Effective and toxic doses are very similar, but case reports of higher colchicine doses inducing acute toxicosis is rare.Case presentationA 19-year-old woman was sent to the emergency room for taking 80 colchicine tablets (0.5mg per tablet) 44h previously. The main physical symptom was abdominal pain. Following ingestion, the patient suffered multi-system failure including renal, respiratory, circulatory, and digestive. Continuous renal replacement therapy (CRRT) and other treatment measures were used to remove metabolic wastes and poisons, and to treat other complications. Renal function was restored after a series of treatments.ConclusionWe report a case of an acute kidney injury induced by an overdose of colchicine. CRRT and a series of related treatments were beneficial for the treatment of colchicine poisoning.

• 出版日期2018-10-30
• 单位南方医科大学; 汕头大学