A Summary of the Iodine Supplementation Study Protocol (I2S2): A UK Multicentre Randomised Controlled Trial in Preterm Infants

作者：Williams Fiona^*; Hume Robert; Ogston Simon; Brocklehurst Peter; Morgan Kayleigh; Juszczak Edmund

来源：Neonatology, 2014, 105(4): 282-+.

DOI：10.1159/000358247

• Iodine supplementation
• Preterm infants
• Randomised controlled trial

This paper summarises the study protocol for the randomised controlled trial of iodine supplementation in preterm infants. Iodine is essential for the synthesis of thyroxine, and thyroxine is essential for normal brain development in utero and for the first 2-3 years of life. The recommended iodine intake in parenteral nutrition regimens is 1 mu g/kg/day and commercially available parenteral solutions for infants reflect these recommendations. In the absence of other iodine sources, infants are vulnerable to negative iodine balance and insufficiency. As many preterm infants are fed parenterally for prolonged periods with solutions which have been shown to be iodine-deficient, the I2S2 Trial was designed to establish whether iodine supplementation of preterm infants benefits neurodevelopment.

• 出版日期2014