摘要
This paper describes how angle-dependent resonances from molded plasmonic crystals can be used to improve real-time biosensing First, an inexpensive and massively parallel approach to create single-use, two-dimensional metal nanopyramidal gratings was developed Second, although constant in bulk dielectric environments, the sensitivities (resonance wavelength shift and resonance width) of plasmonic crystals to adsorbed molecular layers of varying thickness were found to depend on incident excitation angle Third, protein binding at dilute concentrations of protein was carried out at an angle that optimized the signal to noise of our plasmonic sensing platform This angle-dependent sensitivity, which is intrinsic to grating-based sensors, is a critical parameter that can assist in maximizing signal to noise
- 出版日期2010-7
- 单位西北大学