A plastic stabilizer dibutyltin dilaurate induces subchronic neurotoxicity in rats

作者：Jin, Minghua; Song, Peilin; Li, Na; Li, Xuejun; Chen, Jiajun^*

来源：Neural Regeneration Research, 2012, 7(28): 2213-2220.

DOI：10.3969/j.issn.1673-5374.2012.028.007

• dibutyltin dilaurate
• oxidative damage
• cell cycle
• apoptosis
• ultrastructure
• DNA damage
• brain injury
• sub-chronic poisoning

Dibutyltin dilaurate functions as a stabilizer for polyvinyl chloride. In this study, experimental rats were intragastrically administered 5, 10, or 20 mg/kg dibutyltin dilaurate to model sub-chronic poisoning. After exposure, our results showed the activities of superoxide dismutase and glutathione peroxidase decreased in rat brain tissue, while the malondialdehyde and nitric oxide content, as well as nitric oxide synthase activity in rat brain tissue increased. The cell cycle in the right parietal cortex was disordered and the rate of apoptosis increased. DNA damage was aggravated in the cerebral cortex, and the ultrastructure of the right parietal cortex tissues was altered. The above changes became more apparent with exposure to increasing doses of dibutyltin dilaurate. Our experimental findings confirmed the neurotoxicity of dibutyltin dilaurate in rat brain tissues, and demonstrated that the poisoning was dose-dependent.

• 出版日期2012-10-5
• 单位吉林大学; 吉林省人民医院