NR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination

作者：Kheirbek Mazen A; Tannenholz Lindsay; Hen Rene^*

来源：Journal of Neuroscience, 2012, 32(25): 8696-8702.

DOI：10.1523/JNEUROSCI.1692-12.2012

Adult-generated granule cells (GCs) in the dentate gyrus (DG) exhibit a period of heightened plasticity 4-6 weeks postmitosis. However, the functional contribution of this critical window of plasticity to hippocampal neurogenesis and behavior remains unknown. Here, we show that deletion of NR2B-containing NMDA receptors from adult-born GCs impairs a neurogenesis-dependent form of LTP in the DG and reduces dendritic complexity of adult-born GCs, but does not impact their survival. Mice in which the NR2B-containing NMDA receptor was deleted from adult-born GCs did not differ from controls in baseline anxiety-like behavior or discrimination of very different contexts, but were impaired in discrimination of highly similar contexts. These results indicate that NR2B-dependent plasticity of adult-born GCs is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.

• 出版日期2012-6-20