HOMOLOGY OF GENOME OF AIDS-ASSOCIATED VIRUS WITH GENOMES OF HUMAN T-CELL LEUKEMIA VIRUSES

作者：ARYA SK^*; GALLO RC; HAHN BH; SHAW GM; POPOVIC M; SALAHUDDIN SZ; WONGSTAAL F

来源：Science, 1984, 225(4665): 927-930.

DOI：10.1126/science.6089333

<jats:p>
A T lymphotropic virus found in patients with the acquired immune deficiency syndrome (AIDS) or lymphadenopathy syndrome has been postulated to be the cause of AIDS. Immunological analysis of this retrovirus and its biological properties suggest that it is a member of the family of human T-lymphotropic retroviruses known as HTLV. Accordingly, it has been named HTLV-III. In the present report it is shown by nucleic acid hybridization that sequences of the genome of HTLV-III are homologous to the structural genes (
<jats:italic>gag</jats:italic>
,
<jats:italic>pol</jats:italic>
, and
<jats:italic>env</jats:italic>
) of both HTLV-I and HTLV-II and to a potential coding region called pX located between the
<jats:italic>env</jats:italic>
gene and the long terminal repeating sequence that is unique to the HTLV family of retroviruses.
</jats:p>

• 出版日期1984