A Possible Association of Periodontal Infectious Diseases in Pregnant Women with Isolated Orofacial Clefts in Their Children: A Population-Based Case-Control Study

作者：Banhidy Ferenc; Acs Nandor; Puho Erzsebet H; Czeizel Andrew E^*

来源：Birth Defects Research Part A: Clinical and Molecular Teratology , 2010, 88(6): 466-473.

DOI：10.1002/bdra.20664

• maternal periodontal infectious diseases
• related drug treatment
• smoking habit
• congenital abnormalities
• isolated orofacial cleft

BACKGROUND: The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children. METHODS: The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects. RESULTS: Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip palate (OR with 95% CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy. CONCLUSIONS: The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children. Birth Defects Research (Part A) 88:466-473, 2010.

• 出版日期2010-6