Aspergilazine A, a diketopiperazine dimer with a rare N-1 to C-6 linkage, from a marine-derived fungus Aspergillus taichungensis

作者：Cai Shengxin; Kong Xianglan; Wang Wei; Zhou Huinan; Zhu Tianjiao; Li Dehai^*; Gu Qianqun

来源：Tetrahedron Letters, 2012, 53(21): 2615-2617.

DOI：10.1016/j.tetlet.2012.03.043

• Aspergilazine A
• Diketopiperazine dimer
• Aspergillus taichungensis
• Antiviral activity

A novel diketopiperazine (DKP) dimer, aspergilazine A (1), dimerized by two DKP units via a rare N-1 to C-6 linkage, was isolated from the marine-derived fungus Aspergillus taichungensis ZHN-7-07. The structure was determined by the combination of spectroscopic and Marfey';s methods. Biological evaluation indicated that aspergilazine A (1) had a weak activity against influenza A (H1N1) virus.

• 出版日期2012-5-23
• 单位中国海洋大学