Antisolvent Crystallization of Biapenem: Estimation of Growth and Nucleation Kinetics

作者：Luo, Yang-Hui; Wu, Guo-Gan; Sun, Bai-Wang^*

来源：Journal of Chemical and Engineering Data, 2013, 58(3): 588-597.

DOI：10.1021/je3011997

• PARTICLE-SIZE DISTRIBUTION
• PROCESS ANALYTICAL TECHNOLOGY
• BEAM REFLECTANCE MEASUREMENT
• ATR-FTIR
• LASER BACKSCATTERING
• MODEL IDENTIFICATION
• PRECIPITATION
• OPTIMIZATION
• SPECTROSCOPY
• PARACETAMOL

A process mathematic model of seed batch desupersaturation experiments and induction time experiments for the investigation of growth and nucleation kinetics of biapenem through an antisolvent procedure in water/ethanol (antisolvent) system was developed in this work. The kinetic parameters for growth and nucleation were estimated by using in situ technology: attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy for solute concentration, focused beam reflectance measurement (FBRM) for CLD moments, and particle vision and measurement (PVM) for particle image measurement The challenging aspect for the development of this model was the recovery of crystal size distributions (CSDs) from the chord length distribution (CLD) moments; batch experiments were designed for the estimation of this relationship. The mathematic model in this work was confirmed by a comparison between model predictions and experimental data

• 出版日期2013-3
• 单位东南大学