Glioma diagnostics and biomarkers: an ongoing challenge in the field of medicine and science

作者：Hochberg Fred H^*; Atai Nadia A; Gonda David; Hughes Michael S; Mawejje Brolin; Balaj Leonora; Carter Robert S

来源：Expert Review of Molecular Diagnostics, 2014, 14(4): 439-452.

DOI：10.1586/14737159.2014.905202

• exosomes
• microvesicles
• EGFRvIII
• CNS
• glioma
• isocitrate dehydrogenase 1/2
• biomarker
• extracellular vesicles
• cancer

Glioma is the most common brain tumor. For the more aggressive form, glioblastoma, standard treatment includes surgical resection, irradiation with adjuvant temozolomide and, on recurrence, experimental chemotherapy. However, the survival of patients remains poor. There is a critical need for minimally invasive biomarkers for diagnosis and as measures of response to therapeutic interventions. Glioma shed extracellular vesicles (EVs), which invade the surrounding tissue and circulate within both the cerebrospinal fluid and the systemic circulation. These tumor-derived EVs and their content serve as an attractive source of biomarkers. In this review, we discuss the current state of the art of biomarkers for glioma with emphasis on their EV derivation.

• 出版日期2014-5