Steroids from the Soft Coral Sinularia crassa

作者：Chao, Chih Hua; Chou, Kuei Ju; Huang, Chiung Yao; Wen, Zhi Hong; Hsu, Chi Hsin; Wu, Yang Chang; Dai, Chang Feng; Sheu, Jyh Horng^*

来源：Marine Drugs, 2012, 10(2): 439-450.

DOI：10.3390/md10020439

• Sinularia crassa
• crassarosterosides A-D
• crassarosterol A
• anti-inflammatory activity
• o-tolylthiocarbamate

One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A-D (2-5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher's method. The absolute configurations for the sugar moieties of 2-5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 mu M. In contrast, 1-3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells.

• 出版日期2012-2
• 单位中国医科大学; 中山大学