A new direct synthesis of alpha-methylene- and alpha-alkylidene-beta-lactams

作者：Hussein Marwa; El Dine Assaad Nasr; Fares Fares; Dorcet Vincent; Hachem Ali^*; Gree Rene^*

来源：Tetrahedron Letters, 2016, 57(18): 1990-1993.

DOI：10.1016/j.tetlet.2016.03.083

• Nitrones
• Alkynes
• Kinugasa reaction
• Beta-lactams
• Propargyl derivatives

The Kinugasa reaction applied to alkynes bearing a nucleofuge in propargylic position affords directly, and in fair yields, alpha-methylene- or alpha-alkylidene-beta-lactams.

• 出版日期2016-5-4