A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

作者：Ramirez Jose Luis; Oliveira Giselle de Almeida; Calvo Eric; Dalli Jesmond; Colas Romain A; Serhan Charles N; Ribeiro Jose M; Barillas Mury Carolina^*

来源：Nature Communications, 2015, 6(1): 7403.

DOI：10.1038/ncomms8403

Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to `remember' a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A(4). Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/lipocalin complex.

• 出版日期2015-6
• 单位NIH