Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?

作者：Netterlid Eva^*; Hindsen Monica; Siemund Ingrid; Bjork Jonas; Werner Sonja; Jacobsson Helene; Guner Nuray; Bruze Magnus

来源：Acta Dermato-Venereologica, 2013, 93(1): 50-56.

DOI：10.2340/00015555-1409

• aluminium allergy
• atopic dermatitis
• allergen-specific immunotherapy
• itching nodules
• adjuvant

Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immunotherapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study of children and adults entering allergen-specific immunotherapy was performed using questionnaires and patch-testing. A total of 205 individuals completed the study. In the 3 study groups all subjects tested negative to aluminium before allergen-specific immunotherapy and 4 tested positive after therapy. In the control group 4 participants tested positive to aluminium. Six out of 8 who tested positive also had atopic dermatitis. Positive test results were found in 5/78 children and 3/127 adults. Allergen-specific immunotherapy was not shown to be a risk factor for contact allergy to aluminium. Among those who did develop aluminium allergy, children and those with atopic dermatitis were more highly represented.

• 出版日期2013