Multi-walled Carbon Nanotube Modified Electrode for Sensitive Determination of an Anesthetic Drug: Tetracaine Hydrochloride

作者：Guo, Wei^*; Geng, Mingjiang; Zhou, Lingyun; Chao, Shujun; Yang, Ruimin; An, Huijie; Liu, Huiru; Cui, Changchang

来源：International Journal of Electrochemical Science, 2013, 8(4): 5369-5381.

• Tetracaine hydrochloride
• Multi-walled carbon nanotubes
• Modified electrode
• Electrochemical determination

Carboxylated multi-walled carbon nanotubes (MWNTs) were directly cast on a glassy carbon electrode (GCE) to fabricate a MWNT-modified GCE. The modified electrode exhibited good electrocatalytic activity to the electrochemical oxidation of tetracaine hydrochloride (TCH) with greatly enhanced peak currents and negative shift of oxidation peak potential. The results showed that the electrochemical reaction of TCH was an irreversible, diffusion-controlled and two-electron coupled with two-proton process. Effects of scan rate, pH of electrolyte solution, accumulation condition and the cast volume of MWNTs suspension had been discussed and optimized. Under optimized conditions, the amperometric current-time response on the MWNT-modified electrode was proportional to the TCH concentration in the range of 1.0x10(-7)-2.0x10(-5) mol L-1 with a detection limit (defined as 3Sb/m) of 3.6x10(-8) mol L-1. The proposed method was successfully applied to the determination of tetracaine hydrochloride in commercial tablets. This simple, convenient, sensitive and inexpensive method could possibly be employed in quality control and routine determination of drugs in pharmaceutical formulations.

• 出版日期2013-4
• 单位河南科技学院; 新乡医学院