The same synaptic vesicles drive active and spontaneous release

作者：Wilhelm Benjamin G; Groemer Teja W; Rizzoli Silvio O^*

来源：Nature Neuroscience, 2010, 13(12): 1454-1456.

DOI：10.1038/nn.2690

Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin) in neuromuscular preparations from Drosophila, frog and mouse, as well as rat cultured neurons, we found that the same vesicles participate in active and spontaneous release.

• 出版日期2010-12