Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis

作者:Karuppagounder Vengadeshprabhu; Arumugam Somasundaram; Thandavarayan Rajarajan A; Sreedhar Remya; Giridharan Vijayasree V; Watanabe Kenichi
来源:Drug Discovery Today, 2016, 21(4): 632-639.
DOI:10.1016/j.drudis.2016.02.011

摘要

Atopic dermatitis (AD) is an inflammatory skin disease. Over the past few decades, AD has become more prevalent worldwide. Quercetin, a naturally occurring polyphenol, shows antioxidant, anti-inflammatory, and antiallergic activities. Several recent clinical and preclinical findings suggest quercetin as a promising natural treatment for inflammatory skin diseases. Significant progress in elucidating the molecular mechanisms underlying the anti-AD properties of quercetin has been achieved in the recent years. Here, we discuss the use of quercetin as treatment for AD, with a particular focus on the molecular basis of its effect. We also briefly discuss the approaches to improve the bioavailability of quercetin.

  • 出版日期2016-4