A green method for the synthesis of bis-indolylmethanes and 3,3 '-indolyloxindole derivatives using cellulose sulfuric acid under solvent-free conditions

作者：Alinezhad Heshmatollah^*; Haghighi Asefeh Hagh; Salehian Fatemeh

来源：Chinese Chemical Letters, 2010, 21(2): 183-186.

DOI：10.1016/j.cclet.2009.09.001

• Aldehydes
• Ketones
• Cellulose sulfuric acid
• Bis-indolylmethanes
• 3,3 '-Diindolyloxindole derivatives

A highly efficient green protocol for the preparation of bis-indolylmethanes, bis-2-methylindolylmethanes, bis-1-methylindolylmethanes and 3,3'-diindolyloxindole derivatives from the reaction of indoles with various aldehydes and ketones in the presence of cellulose sulfuric acid under solvent-free conditions is reported. The significant features of this procedure are high yields of the products, mild reaction, solvent-free condition and non-toxicity of the catalyst.

• 出版日期2010-2