Boron Ester-Catalyzed Amidation of Carboxylic Acids with Amines: Mechanistic Rationale by Computational Study

作者：Jiang, Yuan-Ye^*; Hu, Ben; Xu, Zhong-Yan; Zhang, Rui-Xue; Liu, Tian-Tian; Bi, Siwei^*

来源：Chemistry-An Asian Journal, 2018, 13(18): 2685-2690.

DOI：10.1002/asia.201800797

• amidation
• boron
• DFT
• proton shuttles
• self-catalysis

A novel boron ester-catalyzed amidation reaction of carboxylic acids and amines with unprecedented functional group tolerance was recently reported. To gain deeper insights into this reaction, a computational study with density functional theory methods was performed in this manuscript. Calculations indicate that the amidation starts with the condensation of carboxylic acids with the boron ester catalyst. The resulting monoacyloxylated boron species further undergoes the carboxylic acid-assisted nucleophilic addition with amines to generate the amide product and a monohydroxyboron species. The condensation of the carboxylic acid with the monohydroxyboron species with the assistance of an amine regenerates monoacyloxylated boron species to finish the catalytic cycle. The rate-determining step is catalyst regeneration and the amine-coordinated monohydroxyboron species is the resting state in the catalytic cycle. The present results are consistent with the previous NMR study and the observed reaction orders of catalyst and substrates; it is expected to benefit further reaction optimization.

• 出版日期2018-9-17
• 单位曲阜师范大学