A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X

作者：Gao Xingming; Zhu Mengyuan; Fan Haiying; Yang Wenqian; Ni Weijuan; Karnati Vishnu V R; Gao Shouhai; Carson John; Weston Brent^*; Wang Binghe

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(12): 2501-2504.

DOI：10.1016/j.bmcl.2015.04.069

• Biomarker
• Boronolectin
• Optical imaging

Two fluorescent diboronic acid compounds (6a and 6b) with a dipeptide linker were synthesized as potential sensors for cell surface saccharide Lewis X (Le(X)). Compound 6a with a dipeptide (H-Asp-Ala-) as the linker was found to selectively label CHOFUT4 cells, which express Le(x), at micromolar concentrations, while non-Le(x)-expressing control cells were not labeled.

• 出版日期2015-6-15