Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

作者：Gao, Ming; Li, Yi; Xie, Lijuan; Chauvinabc, Remi; Cui, Xiuling^*

来源：Chemical communications, 2016, 52(13): 2846-2849.

DOI：10.1039/c5cc08049e

• DIALKYL H-PHOSPHONATES
• CARBON-PHOSPHORUS FUNCTIONALIZATION
• PALLADIUM-CATALYZED PHOSPHONATION
• P BOND FORMATION
• C-P
• REGIOSELECTIVE PHOSPHONATION
• PHOSPHINE OXIDES
• ACIDS
• ARYL
• DIPHENYLPHOSPHINE

A direct C-H bond phosphonation of quinoxalin-2(1H)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield for 20 examples under transition-metal-free conditions. This protocol tolerates a broad scope of substrates and features practicality, high efficiency, environmental friendliness and atom economy.

• 出版日期2016
• 单位华侨大学