A noncanonical NF-kappa B pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response

作者：Luna Lopez Armando; Gonzalez Puertos Viridiana Y; Romero Ontiveros Jacqueline; Ventura Gallegos Jose L; Zentella Alejandro; Gomez Quiroz Luis E; Koenig**erg Mina

来源：Free Radical Biology and Medicine, 2013, 63: 41-50.

DOI：10.1016/j.freeradbiomed.2013.04.033

• Adaptive response
• Hormesis
• Oxidative stress
• NF-kappa B
• Akt
• PI3K
• PKC
• Bcl-2
• Hydrogen peroxide
• Free radicals

Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 mu M H2O2 for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-kappa B. Interestingly, the noncanonical p50 subunit of the NF-kappa B family is apparently the subunit that participates during the oxidative-hormetic response.

• 出版日期2013-10