Atypical fibroxanthoma: A series of 56 tumors and an unexplained uneven distribution of cases in southeast Germany

作者：Wollina Uwe^*; Schoenlebe Jaqueline; Ziemer Mirjana; Friedling Franziska; Koch Andre; Haroske Gunter; Kaatz Martin; Simon Jan C

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2015, 37(6): 829-834.

DOI：10.1002/hed.23673

• atypical fibroxanthoma
• sarcomas
• Mohs surgery
• risk factors
• geographic distribution

BackgroundAtypical fibroxanthoma is a rare mesenchymal tumor of the head and neck region.
MethodsWe analyzed the files of 3 large dermatology hospitals from the years 2001 to 2013 in southeast Germany.
ResultsWe identified 53 patients (56 tumors) with a male predominance. The mean age was 78.0 years 8.3 years. Mohs surgery was performed in all cases resulting in complete remission in 45 patients. Five patients had a relapse within 2 years, and 4 developed metastases. None of the tumors with a safety margin of 2 cm relapsed. The majority of cases were found in the Dresden region.
ConclusionAtypical fibroxanthoma demonstrates an uneven geographic distribution in southeast Germany that demands further investigations. Mohs surgery with 2 cm safety margins is the treatment of choice. A regular follow-up is recommended.

• 出版日期2015-6