A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin alpha(v)beta(3)

作者:Xiong Liqin; Yu Mengxiao; Cheng Mingjun; Zhang Meng; Zhang Xiaoyan; Xu Congjian*; Li Fuyou
来源:Molecular Biosystems, 2009, 5(3): 241-243.
DOI:10.1039/b820576k

摘要

A one-step SNArH reaction has been used for the synthesis of photostable probe 2, which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.