A New Synthesis of (R)-(-)-Sumanirole (PNU-95666E)

作者：Jean Gerard Ludivine; Mace Frederic; Dentel Helene; Ngo Anh Ngoc; Collet Sylvain^*; Guingant Andre; Evain Michel

来源：Synlett, 2010, 2010(10): 1473-1476.

DOI：10.1055/s-0029-1219942

• quinoline
• reduction-acylation
• asymmetric epoxidation
• (R)-(-)-sumanirole

A twelve-step synthesis of (R)-(-)-sumanirole hydrochloride, starting from quinoline, has been achieved. The key reaction features selective epoxidation of the C3-C4 double bond of a 1,2-dihydroquinoline bearing a chiral auxiliary at N-1.

• 出版日期2010-6