Fast and Convenient Synthesis of Amine-Terminated Polylactide as a Macroinitiator for omega-Benzyloxycarbonyl-L-Lysine-N-Carboxyanhydrides

作者：Ju, Mingjie; Gong, Feirong^*; Cheng, Shujun; Gao, Yun

来源：International Journal of Polymer Science, 2011, 2011: 381076.

DOI：10.1155/2011/381076

• L-LACTIDE
• MOLECULAR-WEIGHT
• POLY(ETHYLENE OXIDE)
• EPSILON-CAPROLACTONE
• TRIBLOCK COPOLYMERS
• BLOCK-COPOLYMER
• POLYMERIZATION
• MECHANISM
• PEPTIDE
• 1,5-DIOXEPAN-2-ONE

Amine-terminated poly (L-lactide) (NH2-PLLA) with various chain lengths were successfully synthesized by sequential tert-butyl-N-(3-hydroxypropyl) carbamate initiated bulk ring-opening polymerization (ROP) of L-lactide (L-LA) in the presence of Stannous(II) 2-ethylhexanoate (Sn(Oct)(2)) and deprotection of the N-tert-butoxycarbonyl (Boc) group at the end of the polymer chain. The polymers obtained were characterized by FT-IR, H-1 NMR, and GPC method. NH2-PLLA thus prepared was used to initiate the polymerization of omega-benzyloxycarbonyl-L-lysine-N-carboxyanhydride (Lys (Z)-NCA), and the result confirmed the high nucleophilicity of the terminal amine group. This method was not only suitable for the preparation of low molecular weight NH2-PLLA, but also quite efficient in the synthesis of high molecular weight samples.

• 出版日期2011
• 单位华东理工大学