Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae

作者：Tian Li Wen; Feng Yunjiang; Tran Trong D; Shimizu Yoko; Pfeifer Tom; Vu Hoan T; Quinn Ronald J^*

来源：Bioorganic & Medicinal Chemistry Letters, 2017, 27(17): 4007-4010.

DOI：10.1016/j.bmcl.2017.07.062

• Achyrodimer F
• Cyclobutane derivative
• Tdp1
• Fungus Cortinariaceae
• DFT calculations

Mass-guided isolation of the dichloromethane/methanol extracts from a specimen of teleomorphic fungus of the family Cortinariaceae resulted in the identification of a new dimeric cyclobutane metabolite, achyrodimer F (1), along with the monomers hispidin (2) and bisnoryangonin (3). Their structures were determined by NMR and MS data analyses. Density Function Theory (DFT) NMR calculations was employed to confirm the chemical structure of achyrodimer F. Compound 1 inhibited tyrosyl-DNA phos-phodiesterase I with an IC50 value of 1 mu M.

• 出版日期2017-9-1