Antiepileptic Drug-Induced Encephalopathy

作者：Hansen N^*; Finzel M; Block F

来源：Fortschritte der Neurologie - Psychiatrie, 2010, 78(10): 590-598.

DOI：10.1055/s-0029-1245632

• valproatic acid (valproate)
• antiepileptic drug-induced encephalopathy
• hyperammonemia
• central nervous system
• epileptic discharges

The clinical features of an antiepileptic drug-induced encephalopathy (ADE) are confusion, reduction of vigilance, neurological deficits or an increase of the seizure frequency In the electroencephalogram a general slowing or epileptic discharges are found. Characteristic are non-toxic blood levels of the antiepileptic drugs. So far an ADE was reported under phenytom, carbamazepine or valproatic acid (valproate) therapy. More seldom, an ADE has been described after the intake of vigabatrine, lamotrigine und topiramate. Potential pathogenic mechanisms of AED are hyperammonemia, intrinsic effects on cerebral receptors, drug interactions, hepatic enzyme interactions, metabolic reasons or paradoxical proconvulsive effects of antiepileptic drugs The medicamentous therapy consists of an immediate discontinuation of the antiepileptic drug.

• 出版日期2010-10