Aligned electrospun nanofibers for ultra-thin layer chromatography

作者：Beilke Michael C; Zewe Joseph W; Clark Jonathan E; Olesik Susan V^*

来源：Analytica Chimica Acta, 2013, 761: 201-208.

DOI：10.1016/j.aca.2012.11.028

• Electrospinning
• Nanofibers
• Chromatography
• Ultra-thin layer chromatography
• Alignment
• Drug analysis

The fabrication and implementation of aligned electrospun polyacrylonitrile (PAN) nanofibers as a stationary phase for ultra-thin layer chromatography (UTLC) is described. The aligned electrospun UTLC plates (AE-UTLC) were characterized to give an optimized electrospun mat consisting of high nanofiber alignment and a mat thickness of similar to 25 mu m. The AE-UTLC devices were used to separate a mixture of beta-blockers and steroidal compounds to illustrate the properties of AE-UTLC. The AE-UTLC plates provided shorter analysis time (similar to 2-2.5 times faster) with improved reproducibility (as high as 2 times) as well as an improvement in efficiency (up to100 times greater) relative to non-aligned electrospun-UTLC (E-UTLC) devices.

• 出版日期2013-1-25