New ruthenium(II)/phosphines/diimines complexes: Promising antitumor (human breast cancer) and Mycobacterium tuberculosis fighting agents

作者：dos Santos Edjane R; Mondelli Melina A; Pozzi Lucas V; Correa Rodrigo S; Salistre de Araujo Heloisa S; Pavan Fernando R; Leite Clarice Q F; Ellena Javier; Malta Valeria R S; Machado Sergio P; Batista Alzir A^*

来源：Polyhedron, 2013, 51: 292-297.

DOI：10.1016/j.poly.2013.01.004

• Ruthenium(II) complexes
• Phosphine/diimine complexes
• Cytotoxity
• Antimycobacterial activity

The synthesis and characterization of ruthenium compounds of the type [RuCl2(P)(2)(NN)] [(P)(2) = (PPh3)(2),dppb = 1,4-bis(diphenylphosphino)butano; dppp = 1,3-bis(diphenylphosphino)propane; NN = 5,5%26apos;-dimethyl-2,2%26apos;dipyridyl (5,5%26apos;-mebipy) or 4,4%26apos;-dimethyl-2,2%26apos;dipyridyl (4,4%26apos;-mebipy)] are described. The complexes were characterized using elemental analysis, UVVis and infrared spectroscopies, cyclic voltammetry, and X-ray crystallography. In vitro evaluation of the complexes, using the MTT methodology, revealed their cytotoxic activities in a range of 5.415.7 mu M against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The in vitro antimycobacterial activities of the complexes had their Minimum Inhibitory Concentration (MIC) for MTB cell growth measured, by the REMA method. The MICs for these complexes were found to be between 12.5 and 25.0 mu g/mL. The results are comparable with the second line drug cycloserine (MIC = 12.550.0 mu g/mL), commonly used in the treatment of TB.

• 出版日期2013-3-4