Association Study of the Serotoninergic System in Migraine in the Spanish Population

作者：Corominas R; Sobrido M J; Ribases M; Cuenca Leon E; Blanco Arias P; Narberhaus B; Roig M; Leira R; Lopez Gonzalez J; Macaya A; Cormand B^*

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2010, 153B(1): 177-184.

DOI：10.1002/ajmg.b.30972

• serotonin
• SNP
• HTR2B
• DDC
• MAOA

In order to evaluate the contribution of 19 serotonin-related genes to the susceptibility to migraine in a Spanish population we performed a case-control association study of 122 single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters, in 528 migraine patients -308 with migraine without aura (MO) and 220 with migraine with aura (MA)- and 528 sex-matched migraine-free controls. The single-marker analysis identified nominal associations with the migraine phenotype or with the MO or MA subtypes. The multiple-marker analysis revealed risk haplotypes in three genes that remained significantly associated with migraine after correction by permutations. Two-marker risk haplotypes were identified in the HTR2B (rs16827801T-rs10194776G) and MAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2O44859T-rs11761683G). The present study supports the involvement of HTR2B and MAOA genes in the genetic predisposition to MO, while DDC might confer susceptibility to MA. These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA.

• 出版日期2010-1