An alternative route to the arylvinyltriazole nucleosides

作者：Chudinov Mikhail V^*; Prutkov Alexander N; Matveev Andrey V; Grebenkina Lyubov E; Konstantinova Irina D; Berezovskaya Yulia V

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(14): 3223-3225.

DOI：10.1016/j.bmcl.2016.05.072

• Triazole nucleosides
• Nucleoside analogues
• HCV

A new pathway to synthesis of arylvinyl ribavirin analogues is developed which makes it possible to obtain not only trans- but also cis-isomers at vinyl bond. By this route eight ribavirin 5-arylvinyl analogues are synthesized and their antiviral activity is evaluated.

• 出版日期2016-7-15