Alterations in white matter integrity in first-episode, treatment-naive patients with somatization disorder

作者：Zhang, Jian; Jiang, Muliang; Yao, Dapeng; Dai, Yi; Long, Liling; Yu, Miaoyu; Liu, Jianrong; Zhang, Zhikun; Xiao, Changqing; Guo, Wenbin^*

来源：Neuroscience Letters, 2015, 599: 102-108.

DOI：10.1016/j.neulet.2015.05.037

• Somatization disorder
• White matter
• Diffusion tensor imaging
• Tract-based spatial statistics

White matter (WM) abnormality in somatization disorder (SD) has not been reported yet. This study was designed to elucidate the alterations in WM integrity in SD. A total of 25 patients with SD and 28 healthy controls were enrolled in the study. WM integrity was analyzed using tract-based spatial statistics. No differences were found between the patients and the controls for fractional anisotropy (FA) values, mean diffusivity (MD), axial diffusivity, and radial diffusivity values at the corrected p < 0.05 level. Patients with SD had significantly decreased FA values in the cingulum and inferior fronto-occipital fasciculus, and significantly increased MD values in the anterior thalamic radiation and corticospinal tract compared with the controls at the uncorrected p < 0.005 level. Somatization severity was correlated with the FA values of the cingulum and inferior fronto-occipital fasciculus in the patients. The patients exhibit-suggestive alterations in WM integrity in the cingulum, inferior fronto-occipital fasciculus, anterior thalamic radiation, and corticospinal tract.

• 出版日期2015-7-10
• 单位上海市精神卫生中心; 广西医科大学