Arginine Wettability and Impedance Dual-Signal Response by Aldehyde Calix[4]arene Self-Assembled Monolayers

作者：Yang, Lanlan; Luo, Li; Zhang, Guifen; Miao, Fajun; Zhang, Xiaoyan; Tian, Demei; Li, Haibing^*

来源：ChemPlusChem, 2013, 78(12): 1517-1522.

DOI：10.1002/cplu.201300236

• amino acids
• calixarenes
• monolayers
• self-assembly
• sensors

A new aldehyde calix[4]arene (C4AH) was synthesized efficiently to give a yield of 90% and was used to form self-assembled monolayers (SAMS) by means of click chemistry to give a highly selective wettability and impedance sensor for arginine (Arg). The success of the C4AH functional interface and Arg-responsive events were confirmed by contact-angle (CA) measurements and electrochemical impedance spectroscopy (EIS). Furthermore, the C4AH functional interface can be used as wettability-responsive cycles at least eight times. This type of sensor operates on the principle that Arg has a high pK(a) value of 12.48, and is able to form strong hydrogen bonds with aldehyde selectivity, which results in a significant CA change. The proposed wettability-sensing devices display a remarkable specificity, intuitiveness, and convenience, which should be suitable for the production of arginine recognition chips that can be used in the fields of biology and medical science.

• 出版日期2013-12
• 单位华中师范大学