Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels

作者：Hasegawa Shinya^*; Noda Kazuki; Maeda Akina; Matsuoka Masaru; Yamasaki Masahiro; Fukui Tetsuya

来源：Molecular Genetics and Metabolism, 2012, 107(3): 553-560.

DOI：10.1016/j.ymgme.2012.08.017

• Ketone body
• Cholesterol
• SREBP-2
• Acetoacetyl-CoA synthetase

Ketone bodies have been regarded as an energy source that is mainly produced in the liver, and exported to extrahepatic tissues. However, ketone bodies have also been suggested to be used during the lipogenesis by the ketone body-utilizing enzyme, acetoacetyl-CoA synthetase (AACS). To elucidate the physiological role of AACS in the liver, we investigated the mechanism of transcription of the AACS gene and performed knockdown experiments. We showed that SREBP-2 regulates the expression of AACS and that knockdown of AACS in vivo, by the hydrodynamics method, resulted in the reduction of total blood cholesterol. These results suggest that ketone body metabolism via AACS activity plays an important role in cholesterol homeostasis.

• 出版日期2012-11