Assessment of Irisin, Adiponectin and Leptin Levels in Patients with Schizophrenia

作者：Erzin Gamze^*; Topcuoglu Canan; Kotan Vahap O; Bayram Senol; Fountoulakis Kostas

来源：Endocrine, Metabolic and Immune Disorders - Drug Targets, 2018, 18(2): 163-169.

DOI：10.2174/1871530318666171207142901

• Adipokine
• adiponectin
• antipsychotics
• irisin
• leptin
• metabolic syndrome
• schizophrenia

Background: The patients with schizophrenia are at increased risk for problems regarding metabolic parameters due to their lifestyle and antipsychotic treatment.
Objective: In this study, we aimed to evaluate the levels of adiponectin, leptin, irisin in patients with schizophrenia who were nondiabetic, nonobese and under antipsychotic treatment.
Method: 5 ml sample of venous blood was collected from each participant. Blood cells were separated from the serum. The serum samples were stored in a -80 degrees C freezer. Biochemical analyses were performed on these samples. Adiponectin, leptin and irisin levels were measured by Enzyme Linked Immunosorbent Assay method.
Results: The study included 88 subjects. Of them, 44 were patients with schizophrenia and 44 were healthy controls. There were no statistically significant results when the c-reactive protein, adiponectin, leptin and irisin levels were compared between the schizophrenia and the control group (p>0.05).
Conclusion: In our study, adiponectin, leptin and irisin levels in patients with schizophrenia did not present a statistically significant difference from healthy controls. Therefore, there is a need for studies including more participants to investigate the level of irisin in patients with schizophrenia.

• 出版日期2018