Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer

作者：Yang Yongshou; Nirmagustina Dwi Eva; Kumrungsee Thanutcha****^*; Okazaki Yukako; Tomotake Hiroyuki; Kato Norihisa

来源：Bioscience Biotechnology and Biochemistry, 2017, 81(9): 1796-1804.

DOI：10.1080/09168451.2017.1343117

• Ganoderma lingzhi
• short-chain fatty acids
• secondary bile acids
• mucins
• colon

Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for threeweeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta. Fecal mucins and cecal propionate were significantly elevated by both extracts, and fecal IgA was significantly elevated by WGL, but not by AWGL. These results suggest that the reishi extracts have an impact on colon luminal health by modulating secondary bile acids, microflora, mucins, and propionate that related to colon cancer.

• 出版日期2017