Ag(I)-Catalyzed Regioselective Ring-Opening of N-Tosylaziridine and N-Tosylazetidine with S-, O-, and N-Nucleophiles and Tethered Dinucleophiles

作者：Bera Milan; Pratihar Sanjay; Roy Sujit^*

来源：Journal of Organic Chemistry, 2011, 76(5): 1475-1478.

DOI：10.1021/jo102285z

[Ag(COD)(2)]PF6 catalyzes the ring-opening of N-tosylaziridines and -azetidines with alcohols, amines, thiols, and related tethered 1,2-ethane dinucleophiles. Initial rate studies and DFT-based evaluation of stepwise energetics suggest an inverse relationship between the nucleophilic reactivity of a heteroatom donor and its binding affinity to cationic Ag(I).

• 出版日期2011-3-4