Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals

作者：Parri A; Fito Montserrat^*; Torres C F; Munoz Aguayo D; Schroeder H; Cano J F; Vazquez L; Reglero G; Covas Maria Isabel^*

来源：InflammoPharmacology, 2016, 24(2-3): 127-131.

DOI：10.1007/s10787-016-0265-4

• Alkylglycerols
• Complement 3
• Complement 4
• Vascular endothelial growth factor
• Obesity
• Inflammation

Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.

• 出版日期2016-6