Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to N-Boc Imines and Nitroalkenes

作者:Best Daniel; Kujawa Szymon; Lam Hon Wai*
来源:Journal of the American Chemical Society, 2012, 134(44): 18193-18196.
DOI:10.1021/ja3083494

摘要

A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.

  • 出版日期2012-11-7