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摘要
Backgroud: The effect of dexmedetomidine on surgical stress has still not been documented when compared with propofol. Objective: Our aim was to compare the effects of dexmedetomedine and propofol on stress response in patients undergoing open esophagectomy under total intravenous anesthesia and study the feasibility of dexmedetomedine as the sole anesthetic agent in total intravenous anesthesia (TIVA). Methods: Thirty patients of ASA I similar to II, 60-75 years of age, scheduled for open esophagectomy under general anesthesia were randomly divided into two groups of 15 each. Group P received propofol 2 mg/kg bolus followed by infusion 100 similar to 200 mu g/kg/min and Group D received dexmedetomidine 1 mu g/kg bolus followed by infusion 0.04 similar to 0.08 mu g/kg/min. Both groups were administered standard general anesthesia with routine monitoring. Bispectral index (BIS) were applied to monitor the depth of anesthesia with the target BIS value setting 50 similar to 5 intraoperatively by adjusting the dose of sedative drug. Blood samples were tested for plasma concentrations of epinephrine, norepinephrine, cortisol, ACTH, IL-6 at piror anesthesia, 2 h after surgery and 24 h postoperatively. Modified Brice questionnaire was used to define intraoperative awareness 24 h after operation. Results: Plasma NE, epinephrine, cortisol, ACTH levels in both groups increased significantly at T1, T2, while NE, epinephrine level were significantly higher in P group. Plasma IL-6 concentrationsin in both groups increased with time, while was higher in P group at two time points. Plasma glucose levels increased versus baseline at T1, and significantly higher in D group. Conclusions: Dexmedetomidine has similar effect on surgical stress response in patients undergoing open esophagectomy under general anaesthesia compared with propofol. Then, dexmedetomidine can be used as the sole anesthetic agent in total intravenous anesthesia.
- 出版日期2016
- 单位江苏大学
