Tomenphantadenine, an unprecedented germacranolide-adenine hybrid heterodimer from the medicinal plant Elephantopus tomentosus L.

作者：Guo, Zhi Kai; Wang, Bei; Cai, Cai Hong; Huang, Sheng Zhuo; Yuan, Jing Zhe; Mei, Wen Li^*; Dai, Hao Fu^*

来源：Fitoterapia, 2018, 125: 217-220.

DOI：10.1016/j.fitote.2017.11.022

• Elephantopus tomentosus
• Medicinal plant
• Sesquiterpene lactone
• Antibacterial activity

An unusual adenine-substituted germacrane sesquiterpene lactone, tomenphantadenine (1), has been isolated from the whole plant of Elephantopus tomentosus L. The structure of this compound was established by comprehensive spectroscopic analysis including high resolution (HR) ESI-MS, 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. This compound features novel hybrid pattern of germacrane sesquiterpene with adenine through C-N linkage, and a possible biosynthetic pathway for it was proposed. Compound 1 showed potent antibacterial activity against the gram-positive Staphylococcus aureus and weak acetylcholinesterase (AChE) inhibitory activity.

• 出版日期2018-3
• 单位中国热带农业科学院